General Information

  • ID:  hor004061
  • Uniprot ID:  B3EWL1
  • Protein name:  CAPA-Pyrokinin
  • Gene name:  NA
  • Organism:  Delia radicum (Cabbage root fly) (Anthomyia brassicae)
  • Family:  Pyrokinin family
  • Source:  animal
  • Expression:  Detected in larvae. |Both CAPA-pyrokinin and CAPA-pyrokinin(2-15) are expressed in CNS, ring gland and abdominal perisympathetic organs (aPSO) but not in midgut or thoracic perisympathetic organs (tPSO) (at protein level).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Delia (genus), Anthomyiinae (subfamily), Anthomyiidae (family), Muscoidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AGPSATTGVWFGPRL
  • Length:  15
  • Propeptide:  AGPSATTGVWFGPRL
  • Signal peptide:  NA
  • Modification:  T15 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Mediates visceral muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004061_AF2.pdbhor004061_ESM.pdb

Physical Information

Mass: 176661 Formula: C70H105N19O19
Absent amino acids: CDEHIKMNQY Common amino acids: G
pI: 10.55 Basic residues: 1
Polar residues: 6 Hydrophobic residues: 6
Hydrophobicity: 16 Boman Index: -275
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 58.67
Instability Index: 1148.67 Extinction Coefficient cystines: 5500
Absorbance 280nm: 392.86

Literature

  • PubMed ID:  22848525
  • Title:  Peptidomics of the Agriculturally Damaging Larval Stage of the Cabbage Root Fly Delia Radicum (Diptera: Anthomyiidae)